Information for Medical Professionals

Personalized Tumor Treatment
Novalis TxTM Image-Guided Radiosurgery

Novalis Tx™ incorporates advanced imaging, treatment planning and treatment delivery technologies from Varian Medical Systems and BrainLAB, enabling fast, highly precise, non-invasive radiosurgery treatments for cancerous and non-cancerous conditions of the entire body.

Novalis Tx offers the highest industry dose rate for radiation treatment available for treatment of even the most deep-seeded tumors. Its versatility makes it possible for doctors to treat a wide range of indications and tailor treatment to each patient.

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What are the benefits of Novalis Tx ?

Novalis Tx offers a full spectrum of treatment benefits:

• The 2.5 mm HD120® high-definition multi-leaf collimator offers ultra-fine beam-shaping capabilities. HD120 shapes the radiation beam to match the exact contour of the tumor or lesion ensuring the maximum prescribed dose of high-energy radiation is delivered to the entire tumor
• Protects surrounding healthy tissue
• Adapts the treatment beam to breathing and other body movements to continuously maintain safe, complete and accurate dose delivery

• Non-invasive, outpatient procedure lasts just 15 to 20 minutes, rather than hours, for a more comfortable and less restricted treatment experience than other radiosurgery devices
• Reduces the likelihood of patient or tumor movements, ensuring the highest possible level of treatment accuracy
• Treatment can take place in a single day, although a doctor will decide if treatment should be administered in a single dose or in a series of doses

• Offers frameless and frame-based treatment of cranial indications as well as extra-cranial treatment of spine, lung, liver and prostate lesions
• Employs a wide range of treatment modalities—single stage, hypo- and hyper-fractionation; circular and conformal beams; dynamic conformal arcs; IMRT—ensuring patients receive the best treatment for their individual case. Other radiosurgery devices are limited to only one treatment modality.
• Delivers a dose rate of 1,000 MU per minute, penetrating deeper to treat tumors previously considered untreatable
• Offers hope to patients with clinical conditions once considered untreatable and those for whom surgery is not an option

• Frameless radiosurgery offers a more patient-friendly alternative to other radiosurgery devices that require immobilization with a head ring that attaches to the skull

What types of conditions can Novalis Tx treat?

Novalis Tx treats cancerous and non-cancerous conditions of the entire body such as:

• Arteriovenous malformations (AVM)
• Cavernous angiomas
• Trigeminal neuralgia
• Intractable seizures
• Parkinson’s disease
• Brain metastases/Gliomas
• Acoustic neuromas
• Pediatric brain tumors
• Recurrent brain tumors
• Pituitary adenomas
• Meningiomas of the skull base
• Craniopharyngiomas
• Spine Tumors/Metastases
• Prostate Cancer/Metastases
• Liver Tumors/Metastases
• Lung Tumors/Metastases

How does Novalis Tx work?

Novalis Tx incorporates a powerful linear accelerator, which rotates around the patient to deliver treatment beams anywhere in the body from virtually any angle. A set of sophisticated image-guidance and motion management tools provide clinicians with detailed information about the shape, size and position of the targeted lesion; guide patient setup and positioning; and monitor motion during treatment.

There are tools for synchronizing treatment with the patient's breathing patterns to compensate for tumor motion while treating in or near the lungs. A high-definition multi-leaf collimator, a beam shaping device, ensures that the treatment beam matches the shape of the tumor from every angle as the linac rotates.
What is the treatment advantage of Novalis Tx over other radiosurgery devices?

Other radiosurgery devices utilize circular beams to treat. As most lesions are irregular in shape, a circular dose does not completely cover the exact shape of the tumor. Novalis Tx shapes the radiation beam to contour to the exact shape of the tumor or lesion, ensuring the optimal treatment dose is delivered and protecting healthy tissue. The targeted beam adapts to breathing and other body movements to continuously maintain safe, complete and accurate dosage.

Why is fast treatment important?
Prolonged treatment times can affect patient comfort and treatment accuracy. Fast treatment reduces the likelihood of patient or tumor movements, which can impact overall accuracy. In addition to offering one of the industry’s fastest treatment times, Novalis Tx continuously tracks patient and tumor motion and automatically adjusts the beam of radiation to maintain the highest possible level of treatment accuracy.

Can Novalis Tx perform radiotherapy?
Novalis Tx offers both stereotactic radiosurgery and fractionated stereotactic radiotherapy treatments. Unlike some treatment devices, Novalis Tx can provide a high number of treatment fractions. Studies have shown that fractionated treatment is necessary to ensure effective treatment for some tumors and protect healthy tissue. This is particularly true for tumors near auditory nerves where extending treatment over a number of fractions can provide better treatment outcomes and preserve the patient’s hearing.

What effect can radiation have on a tumor or lesion?
Radiosurgery and radiotherapy use high-energy radiation beams to deliver the prescribed radiation dose directly to tumor cells, causing them to die. Treatment results, visible on follow-up scans, may include shrinkage of the tumor or no further tumor growth. Because cell destruction and absorption of the cells within a patient’s system can be a lengthy process, it can take up to six months before the effect of treatment can be determined by doctors.

Are there any side effects?
Novalis Tx treatment is not painful in most cases and does not require anesthesia. There is typically no scarring or disfigurement and little risk of infection, compared to conventional surgery.
Patients may experience a headache, dizziness and fatigue immediately following treatment, so driving is not recommended. A patient’s doctor will discuss specific side effects that may occur depending on the overall treatment plan.